Jeanine D'Armiento M.D., Ph.D.
Associate Professor of Medicine in Anesthesiology
Director of the Center for Molecular Pulmonary Disease in Anesthesiology and Physiology and Cellular Biophysics - Director, Center for LAM and Rare Lung Disease
The role of matrix metalloproteases in disease and the inhibition of these enzymes as potential therapy in destructive lung diseases.
Jeanine M. D’Armiento is a Professor of Medicine in Anesthesiology at Columbia University. Dr. D’Armiento is Director of the Center for Molecular Pulmonary Disease in Anesthesiology and Physiology and Cellular Biophysics, and Director of the Center for Lymphangiomyomatosis (LAM) and Rare Lung Disease. Dr. D’Armiento’s research focuses on understanding the mechanisms of lung injury and repair. Her laboratory integrates both in vitro and in vivo approaches and is uniquely situated to characterize the molecular changes in the study of lung injury and disease so as to identify potential therapeutic targets. Dr. D’Armiento’s clinical work focuses on Rare Disease, and she is the Director of the Center for LAM and Rare Lung Diseases at Columbia University, which serves one of the largest populations of women with LAM in addition to patients with Alpha-1 Antitrypsin deficiency. She presently serves on the Executive Board of the Alpha-1 Foundation and as a Consultant to the Director of the Office of Rare Disease, NCATs. In addition, Dr. D’Armiento serves on the Executive committee of the Columbia University senate and Chairs the Commission on the Status of Women at the University.
Sonett, J., Goldklang, M., Sklepkiewicz, P., Gerber, A., Trishler, J., Zelonina, T., Westerterp, M., Lemaitre, V., Okada, Y., and D’Armiento, J. A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure (2018) In Press, Faseb J.
Mazumder, S., Lee, A., Dube, B., Teneja, S., Mehra, D., Yan, B., Chillrud, S., Bhandari, N., and D’Armiento, J. Respiratory health and effects of biomass smoke exposure. (2018). Scientific Reports Under Revision.
Turner, D.L., Goldkang, M.P., Trischler, J., Cvetkovski, F., D’Armiento, J.M., and Farber, D.L. Generation and in situ activation of lung tissue-resident memory CD4 T cells in the pathogenesis of allergic asthma. (2018) In Press J. Immunology.
Unachukwu U, Trischler J, Goldklang M, Xiao R, D'Armiento J. Maternal smoke exposure decreases mesenchymal proliferation and modulates Rho-GTPase-dependent actin cytoskeletal signaling in fetal lungs. Faseb J 2017;31(6):2340-2351.
Toba H, Cannon PL, Yabluchanskiy A, Iyer RP, D'Armiento J, Lindsey ML. Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis. Am J Physiol Heart Circ Physiol 2017;312:H375-H83.
Geraghty P, Baumlin N, Salathe MA, Foronjy RF, D'Armiento JM. Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure. Mediators Inflamm 2016;2016:9461289.
Xie T, Liang J, Liu N, Huan C, Zhang Y, Liu W, Kumar M, Xiao R, D'Armiento J, Metzger D, Chambon P, Papaioannou VE, Stripp BR, Jiang D, Noble PW. Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis. J Clin Invest 2016;126:3063-79.