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As the mysteries of the human genome are revealed it is ever more important to understand the functional consequences of genetic variants. Physiology provides the key to unlock these mysteries and bring us to future new understandings that will alleviate human miseries."

— Andrew Marks


Columbia University in NYC



Research Areas



Uncovering the biological mechanisms by which nervous systems mediate behavior. Research in the neurobiology focus area spans molecular, cellular, circuit, and systems level physiology to understand the development and function of the nervous system, and mechanisms that contribute to neurological and neuropsychiatric diseases.


Structural biology

Unraveling principles that govern structure and function of macro-molecules. Research in the Structural Biology focus area uses state-of-the-art technologies such as cryo-electron microscopy to probe structure and function of biological macromolecules, particularly membrane proteins, at near-atomic resolution.


Cardiovascular physiology

Unveiling fundamental mechanisms underlying heart function and heart disease. Research in the Cardiovascular Physiology focus area includes fundamental investigation of cardio-vascular biology, identifying mechanisms of cardiovascular dysfunction in heart failure, cardiac arrhythmias, and atherosclerosis, as well as developing new translational approaches to treat life-threatening heart disease.


Integrated physiology

Understanding cellular and systems physiology. Research in the Integrated Physiology focus area spans a wide-range of cutting-edge topics including metabolism and mitochondrial function, pulmonary biology, bone biology, skeletal muscle function, and virology. A major thrust is to attain a systems level understanding of human physiology and human disease leveraging emerging omics technologies.

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